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Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections

Overview of attention for article published in Lancet Infectious Diseases, February 2017
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18

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (90th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

news
1 news outlet
twitter
17 tweeters

Citations

dimensions_citation
41 Dimensions

Readers on

mendeley
104 Mendeley
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Title
Potential of marine natural products against drug-resistant fungal, viral, and parasitic infections
Published in
Lancet Infectious Diseases, February 2017
DOI 10.1016/s1473-3099(16)30323-1
Pubmed ID
Authors

Usama Ramadan Abdelmohsen, Srikkanth Balasubramanian, Tobias A Oelschlaeger, Tanja Grkovic, Ngoc B Pham, Ronald J Quinn, Ute Hentschel

Abstract

Antibiotics have revolutionised medicine in many aspects, and their discovery is considered a turning point in human history. However, the most serious consequence of the use of antibiotics is the concomitant development of resistance against them. The marine environment has proven to be a very rich source of diverse natural products with significant antibacterial, antifungal, antiviral, antiparasitic, antitumour, anti-inflammatory, antioxidant, and immunomodulatory activities. Many marine natural products (MNPs)-for example, neoechinulin B-have been found to be promising drug candidates to alleviate the mortality and morbidity rates caused by drug-resistant infections, and several MNP-based anti-infectives have already entered phase 1, 2, and 3 clinical trials, with six approved for usage by the US Food and Drug Administration and one by the EU. In this Review, we discuss the diversity of marine natural products that have shown in-vivo efficacy or in-vitro potential against drug-resistant infections of fungal, viral, and parasitic origin, and describe their mechanism of action. We highlight the drug-like physicochemical properties of the reported natural products that have bioactivity against drug-resistant pathogens in order to assess their drug potential. Difficulty in isolation and purification procedures, toxicity associated with the active compound, ecological impacts on natural environment, and insufficient investments by pharmaceutical companies are some of the clear reasons behind market failures and a poor pipeline of MNPs available to date. However, the diverse abundance of natural products in the marine environment could serve as a ray of light for the therapy of drug-resistant infections. Development of resistance-resistant antibiotics could be achieved via the coordinated networking of clinicians, microbiologists, natural product chemists, and pharmacologists together with pharmaceutical venture capitalist companies.

Twitter Demographics

The data shown below were collected from the profiles of 17 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Indonesia 1 <1%
Unknown 103 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 19%
Student > Ph. D. Student 18 17%
Student > Bachelor 12 12%
Researcher 10 10%
Professor 6 6%
Other 21 20%
Unknown 17 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 19%
Chemistry 18 17%
Pharmacology, Toxicology and Pharmaceutical Science 10 10%
Biochemistry, Genetics and Molecular Biology 9 9%
Immunology and Microbiology 7 7%
Other 16 15%
Unknown 24 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 18. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#1,012,343
of 14,563,066 outputs
Outputs from Lancet Infectious Diseases
#1,197
of 4,008 outputs
Outputs of similar age
#36,819
of 380,080 outputs
Outputs of similar age from Lancet Infectious Diseases
#50
of 129 outputs
Altmetric has tracked 14,563,066 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,008 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 36.5. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 380,080 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 90% of its contemporaries.
We're also able to compare this research output to 129 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.