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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Vitamin D supplementation during pregnancy: Effect on the neonatal immune system in a randomized controlled trial
|
|---|---|
| Published in |
The Journal of Allergy and Clinical Immunology, May 2017
|
| DOI | 10.1016/j.jaci.2017.02.039 |
| Pubmed ID | |
| Authors |
Eve Hornsby, Paul E. Pfeffer, Nancy Laranjo, William Cruikshank, Marina Tuzova, Augusto A. Litonjua, Scott T. Weiss, Vincent J. Carey, George O'Connor, Catherine Hawrylowicz |
| Abstract |
Programming of the immune system during fetal development can influence asthma-related risk factors and outcomes in later life. Vitamin D is a well-recognized immune modulator, and deficiency of this nutrient during pregnancy is hypothesized to influence disease development in offspring. We sought to investigate the effect on neonatal immunity of maternal supplementation with 4400 IU/d vitamin D3 during the second and third trimesters of pregnancy by using a subset of cord blood samples from a randomized, double-blind, placebo-controlled clinical trial (the Vitamin D Antenatal Asthma Reduction Trial). Cord blood samples from neonates born to mothers supplemented with 4400 IU/d (n = 26) or 400 IU/d (n = 25) of vitamin D3 were analyzed for immune cell composition by flow cytometry, Toll-like receptor (TLR) expression by quantitative PCR, and cytokine secretion after stimulation with mitogenic, TLR, and T-cell stimuli by cytometric bead array. Responsiveness to the glucocorticoid dexamethasone was determined. Supplementation of mothers with 4400 IU of vitamin D3 resulted in an enhanced broad-spectrum proinflammatory cytokine response of cord blood mononuclear cells to innate and mitogenic stimuli (P = .0009), with an average 1.7- to 2.1-fold increase in levels of several proinflammatory cytokines (GM-CSF, IFN-γ, IL-1β, IL-6, and IL-8) across stimuli, a higher gene expression level of TLR2 (P = .02) and TLR9 (P = .02), a greater than 4-fold increase in IL-17A (P = .03) production after polyclonal T-cell stimulation, and an enhanced IL-10 response of cord blood mononuclear cells to dexamethasone treatment in culture (P = .018). Vitamin D exposure during fetal development influences the immune system of the neonate, which can contribute to protection from asthma-related, including infectious, outcomes in early life. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 16% |
| Costa Rica | 3 | 12% |
| Venezuela, Bolivarian Republic of | 2 | 8% |
| India | 1 | 4% |
| Mexico | 1 | 4% |
| Panama | 1 | 4% |
| Guinea | 1 | 4% |
| Brazil | 1 | 4% |
| Australia | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 9 | 36% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 72% |
| Scientists | 4 | 16% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 245 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 245 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 40 | 16% |
| Student > Master | 24 | 10% |
| Researcher | 23 | 9% |
| Other | 15 | 6% |
| Student > Ph. D. Student | 13 | 5% |
| Other | 45 | 18% |
| Unknown | 85 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 58 | 24% |
| Nursing and Health Professions | 28 | 11% |
| Agricultural and Biological Sciences | 21 | 9% |
| Biochemistry, Genetics and Molecular Biology | 18 | 7% |
| Immunology and Microbiology | 9 | 4% |
| Other | 20 | 8% |
| Unknown | 91 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 248. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2019.
All research outputs
#152,542
of 25,732,188 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#142
of 11,324 outputs
Outputs of similar age
#3,148
of 328,078 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#6
of 139 outputs
Altmetric has tracked 25,732,188 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 11,324 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 328,078 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 139 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.